Phase 1/2 Study of Intratumoral Injection of STX-001 in Advanced Solid Tumors as Monotherapy or in Combination With Pembrolizumab

This early-phase study tests a new drug called STX-001 injected directly into tumors, either alone or combined with an immunotherapy drug called pembrolizumab. STX-001 is designed to activate the immune system inside the tumor to fight the cancer. This is for people with advanced solid tumors. **You may be eligible if...** - You are 18 or older and weigh more than 40 kg - You have an advanced solid tumor that is accessible for injection and biopsy - Your cancer has not responded to standard treatment or no standard treatment is available - You are in good overall condition - Your blood counts and organ function meet required levels **You may NOT be eligible if...** - Your tumor cannot be safely injected or biopsied - You have active autoimmune disease - You have had major surgery in the past 4 weeks - You are pregnant or breastfeeding - You have active uncontrolled infection or significant heart disease Talk to your doctor to see if this trial is right for you.