RecruitingNCT06252948

Gut Microbiome Studies in Patients With POEMS Syndrome and Other Plasma Cell Disorders


Sponsor

Mayo Clinic

Enrollment

240 participants

Start Date

Dec 29, 2021

Study Type

OBSERVATIONAL

Conditions

Summary

A Study to Evaluate Gut Microbiome with POEMS Syndrome and Other Plasma Cell Disorders


Eligibility

Min Age: 18 Years

Inclusion Criteria1

  • Diagnosed with POEMS syndrome (newly diagnosed or in remission) or with newly diagnosed multiple myeloma (MM), monoclonal gammopathy of undetermined significance (MGUS), amyloid light chain (AL) amyloidosis or healthy controls from their households

Exclusion Criteria7

  • Age under 18 years
  • Pregnancy
  • Substance abuse
  • Antibiotics use or gastrointestinal endoscopy in the 3 months prior to the study participation
  • Chronic gastrointestinal disorder
  • Gastrointestinal surgeries in the past 2 years
  • Chemotherapy (including anti-plasma cell treatment and steroids) or radiation treatment for cancer within the last 2 years or active cancer (other than plasma cell disorder)

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Interventions

OTHERNon-interventional study (observational)

Participants undergo stool sample collection, complete surveys, and have their medical record reviewed on study.


Locations(1)

Mayo Clinic in Rochester

Rochester, Minnesota, United States

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NCT06252948


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