Optimization of Radiation Protection Through Genomic Analyses
Optimization of Radiation Protection Through Genomic Analyses in the Analysis of Changes in Cells of the Hematopoietic System Before and During High Dose External Beam Radiotherapy
University Hospital, Essen
30 participants
Jun 1, 2024
INTERVENTIONAL
Conditions
Summary
The long-term goal is to define "signatures" in the form of genomic changes through sequence analyses of genomic DNA using modern Next Generation Sequencing (NGS) methods, which 1. determine the radiation exposure of humans. 2. provide information about the exposure (dose). 3. determine the radiation quality. 4. predict the repair capacity and radiation resistance of an individual.
Eligibility
Inclusion Criteria1
- ECOG 0/1 no prior treatment no prior cancer diagnosis thoracic or head and neck cancer
Exclusion Criteria1
- prior treatment (chemotherapy, radiotherapy, etc.) prior cancer diagnosis
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Interventions
Alteration of the genome under radiotherapy
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT06253338