RecruitingNCT06253754

Pathophysiological Mechanisms and Implication of Treatment in Postural Puncture Headache

Cerebral Hemodynamics and Cerebrospinal Fluid Dynamics in Postdural Puncture Headache An MRI Study for Exploring the Pathophysiological Mechanisms and Implication of Treatment

Sponsor

Umeå University

Enrollment

160 participants

Start Date

Jan 30, 2024

Study Type

OBSERVATIONAL

Summary

To improve treatment for post dural puncture headache, its pathophysiology needs to be explored. Dural puncture alters CNS dynamics; using advanced MRI, we aim to investigate PDPHs pathophysiology explained by brain movement, cerebral blood flow, CSF dynamics and the effect of epidural blood patch.

Eligibility

Min Age: 20 YearsMax Age: 40 Years

Inclusion Criteria1

Postural puncture headache Age 20-40

Exclusion Criteria5

Other central neurological disorders except the actual
Acute medical condition
Pregnancy
Pacemaker, or other medical implants that are not MRI-compatible
Invasive procedures on the central nervous system or surgery on the spine or brain in the last 12 months.

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Interventions

OTHERMRI examination

All included subjects will be examined with MRI

Locations(1)

Umeå University Hospital

Umeå, Västerbotten County, Sweden

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NCT06253754