Efficacy and Safety of Induction Chemotherapy for Olfactory Neuroblastoma (ESICON)

This trial studies the effectiveness of induction chemotherapy (chemo given before the main treatment) in patients with olfactory neuroblastoma — a rare cancer that starts in nerve cells in the nasal cavity near the brain. The goal is to determine whether adding early chemotherapy to the treatment plan improves outcomes for people with more advanced cases of this rare cancer. **You may be eligible if...** - You are 18 or older with a confirmed diagnosis of olfactory neuroblastoma - Your tumor is stage T2, T3, or T4 (moderately to significantly advanced) - Your cancer has not spread to distant organs - You have signed informed consent **You may NOT be eligible if...** - You have an uncontrolled medical condition that could interfere with treatment - You have a severe neurological or psychiatric illness (including dementia or seizures) - You have an active, uncontrolled infection - You are pregnant or breastfeeding Talk to your doctor to see if this trial is right for you.