Study of Diosmin for the Treatment of Digital Ulcers in Systemic Sclerosis

This trial tests diosmin — a plant-based compound with blood vessel-protecting properties — for treating painful digital ulcers (open sores on the fingers) in people with systemic sclerosis (scleroderma). Scleroderma is a chronic autoimmune disease that causes the skin and blood vessels to harden, reducing blood flow to the fingers and causing difficult-to-heal ulcers. **You may be eligible if...** - You have a confirmed diagnosis of systemic sclerosis (scleroderma) - You have at least one active digital ulcer on your fingers - Your scleroderma medications have not changed in the past 30 days **You may NOT be eligible if...** - Your ulcer is infected or has gangrene - You have a citrus allergy (diosmin is derived from citrus fruits) - You have unstable heart, kidney, or liver disease - You have an active infection of any type - You are currently being treated for cancer or have uncured cancer - You are pregnant or breastfeeding Talk to your doctor to see if this trial is right for you.