Surveillance of the Genetic Signature in Circulating Tumor DNA for Guiding Adjuvant Chemotherapy in Urothelial Carcinoma

This study is investigating whether genetic material from tumor cells circulating in the blood (called ctDNA) can help guide decisions about whether someone with bladder or urinary tract cancer needs additional chemotherapy after surgery. **You may be eligible if...** - You are between 18 and 70 years old - You are in generally good health (ECOG score 0 or 1) - You have had surgery to remove your bladder or urinary tract due to muscle-invasive urothelial carcinoma (a type of cancer involving the urinary lining) - Your cancer has not spread to distant parts of the body - Your blood counts, kidney, and liver function meet minimum requirements **You may NOT be eligible if...** - You received anti-cancer treatment within the past 3 weeks - You participated in another clinical trial within the past 28 days - You had another type of cancer in the past 5 years - Your kidney function is too low for chemotherapy (creatinine clearance below 50 mL/min) - You have significant hearing loss or poor bone marrow function that prevents chemotherapy Talk to your doctor to see if this trial is right for you.