RecruitingNCT06261216

Association Between Lifetime Physical Activity and Exercise and the Development of Wild-type Transthyretin Amyloid Cardiomyopathy

Sponsor

Medical University of Graz

Enrollment

189 participants

Start Date

Feb 16, 2024

Study Type

OBSERVATIONAL

Conditions

Amyloid Cardiomyopathy

Summary

The aim of this study is to investigate the association between increased lifetime physical activity and the development of wild-type transthyretin amyloid cardiomyopathy.

Eligibility

Min Age: 60 Years

Inclusion Criteria4

Confirmed diagnosis of wtATTR-CM including sequencing of the TTR gene; or HF; or healthy proband without a diagnosis of heart disease
Initial diagnosis of respective cardiac disease (wtATTR-CM, HF) after the 6th decade of life; or no cardiac disease (healthy control)
Willingness and ability to provide signed informed consent form (ICF)
Age > 60 years

Exclusion Criteria4

History of severe chronic illness limiting the ability to perform physical activity during the 3rd to 6th decade
A diagnosis of dementia or cognitive impairment
Any other reason resulting in the inability to perform the questionnaire and/or interview
Known disease-causing variant (pathogenic or likely-pathogenic) in the TTR gene

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Interventions

OTHERInterview

* International Physical Activity Questionnaire (IPAQ-SF) * interviewer-administered modified Lifetime Total Physical Activity Questionnaire (LTPAQ) form

Locations(1)

Medical University of Graz

Graz, Austria

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NCT06261216

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