Effect of Antioxydant-enriched Media on Blastocyst Euploidy Rates.
Antioxidants-enriched Single-step vs Global Total Single-step Embryo Culture Media: Effect on Blastocyst Euploidy Rates.
ART Fertility Clinics LLC
500 participants
Feb 1, 2024
INTERVENTIONAL
Conditions
Summary
One of the most sensible factors in IVF culture conditions is the susceptibility of gametes and embryos to an induced increase in reactive oxidative species (ROS) caused by the artificial environment. This study aims to evaluate the impact of using antioxidant-supplemented media during culture to evaluate embryo ploidy rates in a prospective randomized trial using sibling oocytes.
Eligibility
Inclusion Criteria7
- Patients undergoing assisted reproductive technology cycles when ICSI is indicated.
- Patients when Iin vitto fertilization (IVF) is also performed will be included as far as there are enough oocytes for ICSI randomization. However, IVF oocytes will not be used for the study.
- Maternal age 18-43 years old.
- PGT-A cycles with only trophectoderm biopsies on day 5/6/7.
- Patients with more than 6 COCs expected for ICSI.
- Body mass index <35.
- Fresh and frozen ejaculated sperm.
Exclusion Criteria2
- PGT-M cycles
- Fresh and frozen testicular sperm.
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Interventions
Blastocyst will be in continuous culture conditions (parallel antioxidants-enriched culture medium (Gx) and Global total one step media (GT) without refreshment on day 3. A refreshment of the media will be done on D5 in both groups.
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT06261671