Nephroureterectomy With and Without Lymph Node Dissection for Upper Tract Urothelial Cell Carcinoma

This study is comparing two surgical approaches for people with upper urinary tract cancer (cancer in the kidney's collecting system or ureter): surgery with removal of nearby lymph nodes versus surgery without. Researchers want to understand whether removing lymph nodes improves outcomes. **You may be eligible if...** - You are an adult over 18 - You have been diagnosed with upper urinary tract urothelial cancer confirmed by biopsy - You are scheduled to have the affected kidney and ureter surgically removed (nephroureterectomy) - Your cancer has not spread to lymph nodes or distant organs (confirmed by imaging) - You do not have invasive bladder cancer at the same time **You may NOT be eligible if...** - Your imaging shows enlarged lymph nodes suspicious for spread - You have cancer that has spread to distant organs - You have simultaneous muscle-invasive bladder cancer - You are in poor general health or have a life-threatening condition - You have a psychiatric disorder preventing informed consent - You are pregnant Talk to your doctor to see if this trial is right for you.