RecruitingNot ApplicableNCT06263426

Kidney Transplantation From Donors With HIV: Impact on Rejection and Long-Term Outcomes (Expanding HOPE Kidney)

HOPE in Action Kidney Transplantation From Donors With HIV: Impact on Rejection and Long-Term Outcomes

Sponsor

Johns Hopkins University

Enrollment

200 participants

Start Date

May 22, 2024

Study Type

INTERVENTIONAL

Conditions

HIV

Summary

This research is being done to better understand rejection in transplant recipients with HIV who receive kidneys from donors with vs without HIV.

Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is looking at how kidney transplants from HIV-positive donors affect outcomes for HIV-positive recipients, including the risk of rejection and long-term kidney function. **You may be eligible if...** - You are 18 or older - You have HIV and are on treatment with an undetectable or near-undetectable viral load (less than 50 copies/mL) - You have been approved for a kidney transplant at your transplant center - You are not severely underweight due to HIV **You may NOT be eligible if...** - You have had certain serious HIV-related complications such as a brain infection called PML, a severe gut infection (cryptosporidiosis lasting more than a month), or HIV-related brain lymphoma - You are pregnant or breastfeeding Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

OTHERHIV D+/R+

Receipt of kidney transplant from a deceased donor with HIV.

OTHERHIV D-/R+

Receipt of kidney transplant from a deceased donor without HIV.

Locations(13)

University of Alabama at Birmingham

Birmingham, Alabama, United States

University of California, Los Angeles

Los Angeles, California, United States

University of California, San Diego

San Diego, California, United States

University of California, San Francisco

San Francisco, California, United States

Rush University Medical Center

Chicago, Illinois, United States

Ochsner Clinic Foundation

New Orleans, Louisiana, United States

Johns Hopkins University

Baltimore, Maryland, United States

Massachusetts General Hospital

Boston, Massachusetts, United States

New York University

New York, New York, United States

Icahn School of Medicine at Mt. Sinai

New York, New York, United States

Columbia University

New York, New York, United States

Weill Cornell Medical Center

New York, New York, United States

University of Pittsburgh Medical Center

Pittsburgh, Pennsylvania, United States

View Full Details on ClinicalTrials.gov

For the most up-to-date information, visit the official listing.

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NCT06263426

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