RecruitingNot ApplicableNCT06265350

Cryoablation Combined With Cardonilizumab and Bevacizumab in Hepatocellular Carcinoma With Pulmonary Metastases

Cryoablation Combined With Cardonilizumab and Bevacizumab in Hepatocellular Carcinoma With Pulmonary Metastases: A Single-center, Prospective, Randomized Controlled Phase II Study


Sponsor

Sun Yat-sen University

Enrollment

80 participants

Start Date

Feb 2, 2024

Study Type

INTERVENTIONAL

Conditions

Summary

This study intends to evaluate the efficacy and safety of cryoablation combined with Cardonilizumab and Bevacizumab in hepatocellular carcinoma with pulmonary metastases.


Eligibility

Min Age: 18 YearsMax Age: 75 Years

Plain Language Summary

Simplified for easier understanding

This study is testing whether combining cryoablation (freezing tumors) with two immunotherapy drugs can control both liver cancer and lung metastases in patients with hepatocellular carcinoma (primary liver cancer) that has spread to the lungs and has stopped responding to previous treatments. **You may be eligible if...** - You have primary or recurrent liver cancer (hepatocellular carcinoma) - Your cancer has spread to the lungs with 5 to 10 lung spots, each no larger than 5 cm - Your liver tumors are limited to 5 or fewer, taking up less than half the liver - You have already tried standard first-line treatments (like sorafenib or lenvatinib) and they are no longer working - Your liver tumors are currently stable or responding to prior treatment **You may NOT be eligible if...** - You have cancer spread beyond the lungs - Your liver function is severely compromised - You have serious blood clotting problems in the portal vein Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGCadonilimab

Cadonilimab, 375mg,Q3W, IV

DRUGBevacizumab

Bevacizumab, 7.5mg/kg,Q3W, IV

PROCEDURECryoablation

Patients accepted Cryoablation of pulmanary metastases


Locations(2)

Sun Yat-sen University Cancer Center

Guanzhou, Guangdong, China

Sun Yat-sen University Cancer Center

Guanzhou, Guangdong, China

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NCT06265350


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