Long-term Result of DTPA (Diethylenetriamine Pentaacetate) Chelation for Gadolinium Deposition Disease

Inclusion Criteria5

• Age 18 or older,
• Diagnosis of Gadolinium Deposition Disease (GDD) established by treating MD according to current criteria and confirmed by investigator review of screening questionnaire (dx criteria: presence of at least 3 of 8 symptoms-cognitive disturbance, extremity pain, arthralgia, chest wall pain, skin pain, headache, skin induration, and skin hyperpigmentation; and, had an unprovoked 24-hour Gd urine excretion level exceeding the laboratory norm at least 28 days after the symptom-inducing MRI;
• has had five or more 2-day chelation treatments with Ca-DTPA/Zn-DTPA;
• will be at least 2 weeks post the last chelation treatment at the time of completing the patient data-gathering questionnaires.
• no more than 2 years have elapsed since the last DTPA chelation.