RecruitingPhase 3NCT06269900

Dexamethasone for Treating Severe Hospital-acquired Pneumonia in Critically Ill Patients With a Proinflammatory Phenotype

Dexamethasone for Treating Severe Hospital-acquired Pneumonia in Critically Ill Patients With a Proinflammatory Phenotype, an International Phase III, Double-blind, Placebo-controlled, Randomized Trial


Sponsor

Nantes University Hospital

Enrollment

450 participants

Start Date

Mar 26, 2024

Study Type

INTERVENTIONAL

Conditions

Summary

Determine the efficacy of dexamethasone plus standard of care (SOC) as compared to placebo plus SOC for treating severe hospital-acquired pneumonia in critically ill patients with a proinflammatory phenotype; It's an international phase III, double-blind, placebo-controlled, randomized trial.


Eligibility

Min Age: 18 YearsMax Age: 85 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a drug called Dexamethasone and a drug called Placebo for people with hospital-acquired pneumonia. The study is currently recruiting participants at 26 locations. People eligible for this study include aged 18 Years to 85 Years.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGDexamethasone

Dexamethasone phosphate injection is given as a slow injection or infusion (intravenous drip) into the veins.

DRUGPlacebo

Placebo injection is given as a slow injection or infusion (intravenous drip) into the veins.


Locations(26)

Chu Amiens

Amiens, France

CHU Angers

Angers, France

Chu Bordeaux

Bordeaux, France

Chu Bordeaux

Bordeaux, France

CHU Brest

Brest, France

CHU Caen

Caen, France

CHU Clermont - Ferrand

Clermont-Ferrand, France

CHU Clermont-Ferrand

Clermont-Ferrand, France

CHU Clermont-Ferrand

Clermont-Ferrand, France

CHU Beaujon

Clichy, France

CHU Raymond Poincaré

Garches, France

Chu Grenoble

Grenoble, France

CHU Limoges

Limoges, France

CHU Marseille

Marseille, France

Chu Nancy

Nancy, France

CHU Nantes (HGRL)

Nantes, France

CHU Nantes

Nantes, France

CHU Nantes (HGRL)

Nantes, France

Chu Nimes

Nîmes, France

CHU Pitié Salpétrière

Paris, France

CHU Pitié Salpétrière

Paris, France

CHU Poitiers

Poitiers, France

CHU Rennes

Rennes, France

CHU Rennes

Rennes, France

Chu Strasbourg

Strasbourg, France

Chu Toulouse

Toulouse, France

View Full Details on ClinicalTrials.gov

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NCT06269900


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