RecruitingPhase 2NCT06272812
A Study to Evaluate the Efficacy, Safety and Immunogenicity of MTBVAC in Adolescents and Adults Living in a TB Endemic Region.
A Phase 2b, Double-blind, Randomized, Placebo-controlled Study to Evaluate the Efficacy, Safety and Immunogenicity of a Candidate Tuberculosis (TB) Vaccine, MTBVAC, Against TB Disease in Adolescents and Adults Aged 14-45 Years, Living in a TB Endemic Region.
Sponsor
International AIDS Vaccine Initiative
Enrollment
5,500 participants
Start Date
Feb 19, 2025
Study Type
INTERVENTIONAL
Conditions
Summary
A Phase 2b, double-blind, randomized, placebo-controlled study to evaluate the efficacy, safety and immunogenicity of a candidate tuberculosis (TB) vaccine, MTBVAC, against TB disease in adolescents and adults aged 14-45 years, living in a TB endemic region.
Eligibility
Min Age: 14 YearsMax Age: 45 Years
Inclusion Criteria17
- Is male or female aged 14 through 45 years on Study Day 1.
- Has completed the written (or thumb printed and witnessed) informed consent process (participants older than 18 years) or has completed the written parental consent and participant assent process (participants younger than 18 years) before any study-related procedures were performed.
- Participants who, in the opinion of the investigatory, can and will comply with the requirements of the protocol (e.g., to stay in contact with the Clinical Research Centre (CRC), return for follow-up visits)
- Has general good health as confirmed by medical history and physical examination.
- All participants born female who are engaging in sexual activity that could lead to pregnancy must commit to use an acceptable method of contraception from 21 days prior to Study Day 1 and for the 2 months after vaccination. Acceptable contraception includes:
- Condoms (male or female) with or without spermicide
- Diaphragm or cervical cap with spermicide
- Intrauterine device
- Hormonal contraception (combined estrogen and progestogen, or progestogen-only), including contraceptive implant or injectable
- Successful vasectomy in the male partner, considered successful if a woman reports that a male partner has:
- documentation of azoospermia by microscopy (1 year ago) or a vasectomy more than 2 years ago with no resultant pregnancy despite sexual activity post vasectomy
- Not of reproductive potential, such as having undergone hysterectomy, bilateral oophorectomy or tubal ligation, postmenopausal (any age and amenorrhea for at least 6 months and a serum follicle stimulating hormone (FSH) level > 40 IU/L), surgically sterile.
- Sexual abstinence. All participants born female who are not heterosexually active at screening must agree to utilize an acceptable method of contraception if they become heterosexually active as outlined above.
- All male participants should agree to use barrier contraception with their female partners for at least 2 weeks after vaccination.
- Has not shared the same enclosed living space with someone diagnosed with TB for one or more nights or for frequent or extended daytime periods during the 6 months prior to Study Day 1.
- HIV negative at screening.
- Negative clinical screening questionnaire and Xpert MTB/RIF negative sputum sample for pulmonary TB disease at screening.
Exclusion Criteria15
- Acute illness and/or axillary temperature ≥37.5°C on Study Day 1.
- Current suspicion or evidence (including but not limited to sputum Xpert MTB/RIF positive) of active TB disease at any CRC. An attempt must be made to obtain sputum from each participant; persons who are sputum unproductive will be assumed to be Xpert MTB/RIF negative.
- History of previous TB disease and/or treatment for TB disease.
- History of TB preventative therapy, not including BCG vaccination.
- Received any investigational drug or investigational vaccine within 42 days before Study Day 1, or planned use during the study period.
- Planned administration/administration of a licensed vaccine not foreseen by the study protocol in the period starting 28 days before Study Day 1 and ending 28 days after vaccine administration.
- Prior receipt of any investigational TB vaccine candidate before Study Day 1. Note: receipt of placebo in a previous TB vaccine trial will not exclude a participant from participation if documentation is available and the Medical Monitor gives approval.
- Chronic administration of immunosuppressive medication within 42 days before Study Day 1 (inhaled and topical corticosteroids are permitted).
- Any confirmed or suspected immunosuppressive, immunodeficient, or autoimmune condition based on medical history and physical examination (no laboratory testing required).
- Concurrent, or planned participation in any other investigational study during the study period. (Concurrent participation in an observational trial not requiring blood or tissue sample collection is not an exclusion.)
- Received immunoglobulin or blood products within 42 days before Study Day 1, or planned administration during the study period.
- History or any reaction or hypersensitivity likely to be exacerbated by any component of the vaccines.
- Pregnant or lactating/nursing female, or positive urine pregnancy test during screening or pre-vaccination on Study Day 1.
- Indeterminate IGRA test result at screening.
- Any current, or history of, medication use or medical, psychiatric, occupational, or substance abuse problems that, in the opinion of the investigator, might compromise the safety of the participant or make it unlikely that the participant will comply with the protocol.
Interested in this trial?
Get notified about updates and connect with the research team.
Interventions
BIOLOGICALMTBVAC
Vaccine Dose: MTBVAC 5x10\^5 Formulation (approximately, per standard dose): 3 - 17x10\^5 CFU Sucrose Sodium glutamate Presentation: Lyophilized pellet in vials (10 doses) Volume: 0.1 mL/dose Intradermal
BIOLOGICALPlacebo
0.9% saline Volume: 0.1 mL/dose Intradermal
Locations(16)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT06272812
Related Trials
Effectiveness of Computer-Aided Detection Chest X-Ray Screening for Improving Tuberculosis Diagnostic Yield in Chinese Primary Health Care Settings: Study Protocol for a Prospective Cluster Randomized Controlled Trial
NCT069636061 location
Questioning the Epidemiology of Asymptomatic TB
NCT073122661 location
Respiratory Health and Wellbeing Post Pulmonary Tuberculosis
NCT071788601 location
ESAT6/CFP10 Skin Testing for TB Infection in Rheumatologic Patients
NCT067966472 locations
Pharmacist-led Digital Interventions to Improve Tuberculosis Treatment Adherence
NCT070693871 location