RecruitingNot ApplicableNCT06276010
Use of Nafamostat Mesilate for Anticoagulation in Patients With ECMO
Use of Nafamostat Mesilate for Anticoagulation in Patients With Extracorporeal Membrane Oxygenation After Cardiac Surgery: Efficacy and Safety
Sponsor
Xiaotong Hou
Enrollment
80 participants
Start Date
Jul 1, 2024
Study Type
INTERVENTIONAL
Conditions
Summary
The purpose of this study is to evaluate the effectiveness and safety of nafamostat mesilate compared with unfractionated heparin for anticoagulation in patients with ECMO after cardiac surgery.
Eligibility
Min Age: 18 Years
Inclusion Criteria4
- Age ≥ 18 years old
- VA-ECMO or VV-ECMO was accepted after cardiac surgery.
- The ECMO treatment team believes that systemic anticoagulation is needed
- Sign the informed consent form
Exclusion Criteria10
- The researchers believe that there are other causes of active bleeding that are not suitable to participate in this study.
- Long-term use of anticoagulants before establishment of ECMO
- Antiplatelet drugs were used before the establishment of ECMO
- Severe liver insufficiency
- Connective tissue disease
- There is a history of allergy to heparin or nemolastat mesylate.
- Pregnant
- Previous diagnosis of heparin-induced thrombocytopenia
- Expect to die within 48 hours
- ECPR
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Interventions
DRUGnafamostat mesilate
Use nafamostat mesilate as an anticoagulant
DRUGunfractionated heparin group
Use unfractionated heparin as an anticoagulant
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT06276010
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