Resection or Ablation of Small Kidney Tumors
Resection or Ablative Treatment of Small Renal Tumors, a Multicenter Randomized Clinical Trial
Karolinska University Hospital
300 participants
Jan 31, 2024
INTERVENTIONAL
Conditions
Summary
Ablative treatments are believed to have a lower rate of complications, shorter hospital stays, and fewer interventions with benign PAD compared to partial nephrectomies in small kidney cancer lesions. The purpose of the study is to compare complications, the frequency of residual tumors, impact on kidney function, differences in quality of life, and health economic factors in a randomised study. We will also compare the oncological outcomes, including survival and recurrence of kidney cancer.
Eligibility
Inclusion Criteria9
- Age 18 - 99 years
- Patient suitable based on clinical status for both ablative treatment and surgery
- Primary kidney tumor
- Tumor size ≤ 3 cm
- Clinical stage of the tumor T1a (no macroscopic vascular or extrarenal invasion)
- Tumor location suitable for both ablative treatment and resection
- Absence of radiological signs of metastasis
- Biopsy with malignant pathological analysis (PAD)
- ISUP grade I-III"
Exclusion Criteria5
- Radiological signs of metastasis
- Synchronous kidney tumors
- ISUP grade IV or sarcomatoid growth in the biopsy
- Other metastasized cancer in the last 5 years
- Patient unable to make an informed decision to participate in the study
Interventions
Microwave ablation, Radiofrequency ablation, Cryo ablation
Partial or total nefrectomy
Locations(1)
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NCT06278506