Trigeminal Nerve Stimulation in Treatment-resistant Generalized Anxiety Disorder: a Feasibility Study

This feasibility study is testing a non-invasive brain stimulation technique called trigeminal nerve stimulation (TNS) — delivered through a small device worn on the forehead — for people with treatment-resistant generalized anxiety disorder (GAD) who have not responded to at least two different anxiety medications. **You may be eligible if...** - You have a confirmed diagnosis of generalized anxiety disorder (GAD) - You have not responded to at least two different anxiety medications (from different drug classes, taken at adequate doses for at least 8 weeks each) - You are currently on a stable dose of an SSRI or SNRI antidepressant for at least 8 weeks **You may NOT be eligible if...** - You have moderate to severe major depression or significant suicidal thoughts - You have OCD, PTSD, bipolar disorder, schizophrenia, personality disorders, intellectual disability, dementia, or other neurological conditions - You are pregnant or breastfeeding - You have a seizure disorder - You have a vagus nerve stimulator or other electrical implant - You currently use cannabis, illicit drugs, or drink more than 3 alcoholic beverages per week Talk to your doctor to see if this trial is right for you.