Study of Brain-spinal Cord Neural Connectivity in Spasticity
Fondation Ophtalmologique Adolphe de Rothschild
50 participants
Feb 26, 2024
OBSERVATIONAL
Conditions
Summary
Little is known about the peripheral and central mechanisms of action of selective dorsal rhizotomy surgery for the treatment of spasticity. A better understanding of these mechanisms will enable us to improve the surgical procedure. This will require cortico-medullo-radiculo-muscular recordings never before performed and published in the literature, and the identification of variations in connectivity correlated with the clinic.
Eligibility
Inclusion Criteria4
- Patients aged 3 to 17 years included
- scheduled for selective rhizotomy surgery
- Having received informed consent to participate in the study (written consent from both parents)
- Affiliated or beneficiary of a social security scheme
Exclusion Criteria5
- Contraindications to selective rhizotomy
- History of epilepsy
- Known neurological and/or psychiatric disorders with past and/or current medical treatment, or drug addiction
- Patient under legal protection
- Pregnant or breast-feeding women
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Interventions
The procedure involves intraoperative neuroelectrophysiological monitoring. The aim is to record the electrical activity of the central and peripheral nervous system at several levels during a neurosurgical procedure. The equipment used comes from INOMED and consists of : * a recording station (ISIS) * scalp corkscrew electrodes (2 to 4 electrodes) * a 4-pin FSR spinal cord electrode (Ad-Tech) * hook electrodes for roots/radicles (X2) * needle electrodes for muscles (X18) Electrode placement and recording take place in the operating room while the patient is under general anaesthetic (intubated and sedated).
Locations(2)
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NCT06281223