Seeing the Light: Early Intervention in People at Risk for Bipolar Disorder
An Explorative and Experimental Study to Assess the Feasibility, Acceptability, and Effectiveness of Early Intervention With Light, Lifestyle and ImCT Therapy in Individuals at Risk for Bipolar Disorder
Geestelijke Gezondheidszorg Eindhoven (GGzE)
50 participants
May 1, 2024
INTERVENTIONAL
Conditions
Summary
In the current study, the feasibility, acceptability and effectivity of a new add-on early intervention program for individuals at risk for the development of bipolar disorder is evaluated. This intervention program entails psycho-education, light and lifestyle therapy in combination with Imagery focused Cognitive Therapy (ImCT). The program aims to contribute to early intervention by focusing on subclinical mood swings, anxiety symptoms, circadian rhythm and lifestyle factors such as activity level. We hypothesize a relationship between this early intervention and a significant improvement in mood symptoms, anxiety, subjective and objective sleep factors and lifestyle variables. Also, the feasibility, acceptability and associations with clinical improvement of symptoms will be studied. Additionally, in a separate validation study, data will be collected to validate a new instrument for the early detection of those at risk for bipolar disorders. The Semistructured Interview of At Risk Bipolar States (SIBARS) (Fusar-Poli et al., 2022) will be translated and validated in a Dutch sample, in cooperation with its creators, Prof. Dr. P. Fusar-Poli and colleagues.
Eligibility
Inclusion Criteria6
- Must be bound to start the early intervention treatment being evaluated
- Aged 16-35, or > 35 by indication of the patients' treating clinician
- Found to be at risk for SMI, as determined by the Early Detection and Intervention Team of GGzE
- Sufficient knowledge of Dutch or English language
- Ability to give informed consent
- Willing to complete daily monitoring throughout the duration of the study
Exclusion Criteria4
- Learningdifficulties,organicbraindiseaseorsevereneurologicalimpairment.
- Previously received BLT (less than 3 weeks prior to study entry
- Current severe substance or alcohol misuse (clinicians' assessment)
- In case of BLT: eye problems contraindicating BLT and/or being unable to visit the GGzE
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Interventions
Week 1-3: BLT will be administered for 30 minutes on five consecutive days, starting on Monday of the work week, between 7:30 AM and 10:00. The effect of the light therapy is evaluated by means of the Self-Rated Quick Inventory of Depressive Symptoms (QIDS-SR). Further treatment strategy is determined on the basis of these results: * If the patient has achieved remission (QIDS-SR \< 6), BLT has been successful and the patient can continue with PE and IMCT. * If there is insufficient or no response (QIDS-SR of 6 or higher), BLT is extended with five more sessions the following week. * If necessary, a third week is optional. Week 2-4: Psycho Education will follow, 1 session. Week 3/4-9/10: ImCT will follow, 6 sessions.
Week 1-3: blue-light blocking glasses will be administered. Week 2-4: Psycho Education will follow, 1 session. Week 3/4-9/10: ImCT will follow, 6 sessions.
Week 1: Psycho Education, 1 session. Week 2-7: ImCT will follow, 6 sessions.
Locations(1)
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NCT06282250