The HistoSonics Edison™ System for Treatment of Pancreatic Adenocarcinoma Using Histotripsy

This trial is testing a non-invasive procedure called histotripsy for treating pancreatic adenocarcinoma (pancreatic cancer). Histotripsy uses focused ultrasound waves — similar to sound waves — to mechanically destroy tumor tissue without cutting or radiation. The HistoSonics Edison system delivers these pulses from outside the body. **You may be eligible if...** - You are 18 years or older - You have unresectable (cannot be surgically removed) locally advanced (stage 3) or limited-spread (stage 4, up to 5 tumors in liver or lung only) pancreatic adenocarcinoma - You are not a surgical candidate and have already received at least 8 weeks of chemotherapy - You can tolerate general anesthesia - You are in good physical condition (ECOG 0-1) - Your blood counts and organ function are adequate **You may NOT be eligible if...** - You have more than 5 metastatic tumors or spread outside the liver and lungs - Your tumor is smaller than 2 cm - You have significant bleeding problems or are on blood-thinning medication that cannot be paused - You have a pacemaker or other implanted device near the treatment area Talk to your doctor to see if this trial is right for you.