RecruitingPhase 1Phase 2NCT06286189

Trazodone on OSA Endotypes

Effect of Trazodone on Obstructive Sleep Apnea Endotypes and Severity

Sponsor

Brigham and Women's Hospital

Enrollment

18 participants

Start Date

Jan 1, 2024

Study Type

INTERVENTIONAL

Conditions

Obstructive Sleep Apnea

Summary

Obstructive sleep apnea (OSA) is common and has major health implications but treatment options are limited. Some OSA patients with low arousal threshold wake up prematurely during an obstructive event and do not have time for spontaneous upper airway (UA) dilator muscle recruitment. As a consequence they are exposed to apnea and hypopnea cycling. In this protocol the investigators will test the effect of trazodone administered before sleep on OSA traits and OSA severity during sleep.

Eligibility

Min Age: 21 YearsMax Age: 70 Years

Plain Language Summary

Simplified for easier understanding

This clinical trial is studying a drug called Placebo oral tablet and a drug called Trazodone Hydrochloride for people with obstructive sleep apnea. The study is currently recruiting participants at 1 location. People eligible for this study include aged 21 Years to 70 Years.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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