Colorectal Omics and OfCS Proteoglycans
Colorectal OmiCs and Oncofetal Chondroitin Sulfate-modified Proteoglycans
Claus Anders Bertelsen, PhD, MD
1,000 participants
Oct 8, 2024
OBSERVATIONAL
Conditions
Summary
This observational study aims to test proteomics, metabolomics and proteoglycans as predictors of postoperative complications after colorectal surgery and as biomarkers of colorectal cancer. The main questions to answer are: * can these biomarkers predict anastomotic leakages * can these biomarkers predict recurrence after colorectal cancer * can these biomarkers be used as diagnostic tests for colorectal cancer * can these biomarkers be identified in the tumor Participants will undergo elective colorectal resection or stoma closure.
Eligibility
Inclusion Criteria4
- Patients diagnosed or with suspicion of colorectal cancer or adenoma, inflammatory bowel disease, late complications to colon diverticulosis, colostomy reversal or other diagnoses requiring colorectal resection.
- Patients planned to undergo elective surgical procedures coded as KJFB20-KJFB99, KJFG30-37 or KJGB00-97 according to the Danish modification of the NOMESCO Classification of Surgical Procedures
- Able to speak Danish, English, or other languages where professional interpretation is available
- Able to give informed consent
Exclusion Criteria4
- Patients undergoing synchronous: liver resection (patients undergoing metastasectomies can be included); total gastrectomy or cardia resection; Whipple's procedure or another major pancreatic resection (resections of the pancreatic tail can be included); total or partial nephrectomies or cystectomy
- Patients previously included in the study
- Patients known to be pregnant (pregnancy test not required)
- Non-resident in Denmark
Interventions
Elective open or minimally invasive resection for colorectal cancer, IBD or other benign colorectal disorder, or stoma closure
Locations(2)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT06287671