Microbiota in Urine and Urothelium Can be a Factor for Induction of Urinary Bladder Cancer. The Study Will Examine Urine and Bladder Tissues From Egyptian Male Patients and Controls Using Whole Genomic Sequencing Techniques and 16S rRNA. The Aim is to Elucidate Role of Microbiota in Bladder Cancer.

This study is investigating whether specific bacteria (microbiota) in the urine and bladder lining play a role in causing bladder cancer, by analyzing samples from Egyptian men using advanced genetic sequencing techniques. **You may be eligible if...** - You are a male 18 years or older - You have been diagnosed with bladder cancer confirmed by imaging, urine tests, or biopsy **You may NOT be eligible if...** - You have previously had radiation therapy to the bladder or nearby organs - You have received prior BCG immunotherapy or chemotherapy directly into the bladder - You have had prior chemotherapy before surgery (neoadjuvant chemotherapy) Talk to your doctor to see if this trial is right for you.