Study of Acute Normovolemic Hemodilution (ANH) in People With Ovarian Cancer Who Are Having Cytoreductive Surgery

This study is testing a blood conservation technique called acute normovolemic hemodilution (ANH) during surgery for advanced ovarian cancer. ANH involves temporarily removing some of the patient's blood before surgery and replacing it with fluids, then returning the blood during or after surgery to reduce the need for donated blood transfusions. **You may be eligible if...** - You are 18 or older with suspected or confirmed advanced ovarian, fallopian tube, or peritoneal cancer (stage IIIC or IV) - You are scheduled for exploratory abdominal surgery and tumor-removal surgery - Your hemoglobin (a measure of red blood cells) is at least 10 mg/dL within 45 days before surgery - Your surgeon has assessed you as suitable based on a specific scoring system (BLOODS score ≥2) **You may NOT be eligible if...** - You have active heart disease (such as coronary artery disease without a recent normal stress test) - You are scheduled only for diagnostic laparoscopy (not full surgery) - You have other conditions that make blood removal unsafe Talk to your doctor to see if this trial is right for you.