RecruitingNot ApplicableNCT06292286

Secondary Interval Cytoreductive Surgery in Platinum-sensitive Recurrent Epithelial Ovarian Cancer

Secondary Neoadjuvant Chemotherapy and Interval Cytoreductive Surgery in Platinum-sensitive Recurrent Epithelial Ovarian Cancer Patients - a Pilot Study


Sponsor

The University of Hong Kong

Enrollment

18 participants

Start Date

Nov 1, 2023

Study Type

INTERVENTIONAL

Conditions

Summary

About 80% of advanced ovarian cancer patients recurred in 2-3 years. Secondary cytoreduction benefits selected patients who have high chance of complete resection. Whether secondary interval surgery can be used at recurrence is not known.


Eligibility

Sex: FEMALEMin Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is evaluating a second surgery to remove as much remaining cancer as possible (secondary cytoreductive surgery) in women with ovarian, fallopian tube, or peritoneal cancer that has come back after initial treatment and is still responding to platinum-based chemotherapy. **You may be eligible if...** - You have confirmed epithelial ovarian, fallopian tube, or primary peritoneal carcinoma - You have received at least 3 cycles of platinum-based chemotherapy during initial treatment - It has been at least 6 months since your last platinum chemotherapy dose (platinum-sensitive recurrence) - You were not a candidate for full tumor removal upfront - You are in good general health (ECOG 0–2) with adequate organ function **You may NOT be eligible if...** - You have non-epithelial or borderline ovarian tumors - You have had another cancer in the past 5 years (with limited exceptions) - Your cancer is no longer responding to platinum chemotherapy Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

PROCEDURECarboplatin or cisplatin

Carboplatin of cisplatin for 3-6 cycles

DRUGPaclitaxel, gemcitabine or liposomal doxorubicin with or without bevacizumab or biosimilar

Paclitaxel, gemcitabine or liposomal doxorubicin, for 3-6 cycles

DRUGBevacizumab or biosimilar

Optional

PROCEDURECytoreductive surgery

Cytoreductive surgery after chemotherapy


Locations(1)

The University of Hong Kong

Hong Kong, Hong Kong

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NCT06292286


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