RecruitingNCT06295965

Clonal Hematopoiesis and Therapy-Emergent Myeloid Neoplasms in Patients With Cancers, CHANCES Study

Clonal Hematopoiesis and Therapy-Emergent Myeloid Neoplasms in Patients With Cancers (CHANCES)


Sponsor

University of Washington

Enrollment

2,000 participants

Start Date

Jan 2, 2024

Study Type

OBSERVATIONAL

Conditions

Summary

This study is being done to investigate clonal hematopoiesis and therapy-emergent myeloid neoplasms in patients with ovarian or other solid cancers. Researchers want to identify risk factors for developing these blood cancers as well as if there is/are a genetic/environmental component(s) to developing blood cancer.


Eligibility

Plain Language Summary

Simplified for easier understanding

This study, called CHANCES, tracks whether certain cancer treatments — particularly platinum-based chemotherapy or PARP inhibitor drugs — may later lead to the development of blood disorders. Researchers will take blood samples over time to look for early signs of these changes. **You may be eligible if...** - You have or have had ovarian, fallopian tube, or peritoneal cancer and completed at least 5 cycles of platinum-based chemotherapy - OR you have any solid tumor diagnosis and have taken a PARP inhibitor drug (such as olaparib or niraparib) for at least 4 months - OR you have already been diagnosed with a blood disorder such as clonal hematopoiesis or a therapy-related blood cancer - You have a life expectancy of more than 6 months **You may NOT be eligible if...** - Your life expectancy is less than 6 months Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

OTHERNon-Interventional Study

Non-interventional study


Locations(1)

Fred Hutch/University of Washington Cancer Consortium

Seattle, Washington, United States

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NCT06295965


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