An Antibiotic Protocol Guided by a Multimodal Approach in AECOPD With Pneumonia in Intensive Care

This study tests a strategy for deciding when to use antibiotics in ICU patients with a flare-up of COPD (chronic obstructive pulmonary disease) combined with pneumonia. The approach uses multiple tests — including biomarkers and imaging — to guide antibiotic decisions, aiming to reduce unnecessary antibiotic use while still treating serious infections effectively. **You may be eligible if...** - You are over 18 years old - You have COPD (diagnosed or suspected) - You have been admitted to the ICU with community-acquired pneumonia confirmed on chest imaging - You were admitted to the hospital within the past 48 hours - You or your representative has provided informed consent **You may NOT be eligible if...** - You have a weakened immune system (e.g., from cancer treatment, HIV, or immune-suppressing medications) - You are pregnant - You have been hospitalized in the past 3 months (nosocomial infection risk) - You are already being treated for another clinical trial Talk to your doctor to see if this trial is right for you.