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RecruitingNot ApplicableNCT06302296

Evaluating the Effect of Injectable Platelet-rich Fibrin on Accelerating Orthodontic Tooth Movement

Evaluating the Effect of Injectable Platelet-rich Fibrin on Accelerating Orthodontic Tooth Movement During Leveling and Alignment Stage Study Description

Sponsor

Hama University

Enrollment

14 participants

Start Date

Dec 20, 2025

Study Type

INTERVENTIONAL

Conditions

Tooth MobilityInjectable Platelet-rich Fibrin

Summary

One of the main goals of orthodontic treatment is the reduction of treatment time through faster tooth movement. The previous studies evaluating platelet-rich fibrin (PRF) and orthodontic tooth movement (OTM) are limited, which makes the results difficult to generalize.

Eligibility

Min Age: 18 YearsMax Age: 26 Years

Inclusion Criteria4

  • The patient's age (18-26). Severe or very severe irregularity of the upper incisors greater than (7 mm) according to Little's index, so it is recommended to extract the upper first premolar.
  • Class I or Class II malocclusion, first model according to Angle, with skeletal class I or II and a normal or mild vertical growth pattern.
  • All permanent upper teeth, up to the first molar, are present, with the possibility of attaching brackets to all teeth in a correct position.
  • The patient has good oral health.

Exclusion Criteria6

  • • The presence of any systemic disease that affects orthodontic dental movement.
  • Severe malalignment of one of the teeth (palatal quadrant, ectopic canine, ectopic premolar).
  • The patient has undergone previous orthodontic treatment.
  • The patient is subject to any drug treatment that may affect orthodontic dental movement (cortisone, non-steroidal anti-inflammatory drugs).
  • The patient has poor oral health.
  • Commitment to periodic follow-up appointments.
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Interventions

DEVICEinjectable form of PRF

A group of patients in which participants will be undergo to orthodontic treatment will be received a 0.9 ml injection of PRF after 1st premolar extraction.

BEHAVIORALPlacebo injection

A group of patients in which participants will be undergo to traditional orthodontic treatment will be received a Placebo injection after 1st premolar extraction.

Locations(1)

Fadi Jnaid

Hama, Syria

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NCT06302296