Assessing the Convenience of Natural Proliferative Phase Frozen Embryo Transfer
Assessing the Convenience of Natural Proliferative Phase Frozen Embryo Transfer: an Ambispective Cohort Study
Instituto Valenciano de Infertilidade de Lisboa
530 participants
Feb 23, 2024
OBSERVATIONAL
Conditions
Summary
This study will assess the convenience of the natural proliferative phase frozen embryo transfer (NPP-FET) in terms of number of number of appointments needed before cycle scheduling.
Eligibility
Inclusion Criteria7
- Endometrial thickness ≥ 7 mm on the day of starting progesterone-based luteal phase support (LPS)
- Serum progesterone levels \<1.5 ng/ml on the day of starting progesterone-based LPS
- LPS with micronized progesterone 400mg b.i.d.
- Regular cycles (\>24 days, ≤ 38 days)
- IVF/ICSI with donated oocytes
- Single blastocyst stage embryo transfer
- First or second embryo transfer from the same cohort
Exclusion Criteria5
- Use of exogenous ovarian stimulation during FET
- Untreated hydrosalpinx, polyp, submucous myomas or severe adenomyosis
- Recurrent pregnancy loss (≥ 3 previous pregnancy losses)
- Recurrent implantation failure with embryos from oocyte donation (≥ 3 previous failed embryo transfers)
- Personalized initiation of exogenous progesterone according to a previous endometrial receptivity assay test
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Interventions
When endometrial thickness is above 7 mm, vaginal micronized progesterone will be administered 400mg 12/12h when the dominant follicle is at least 13 mm, serum estradiol (E2) levels are \>80 pg/ml, and serum progesterone levels are \<1.5ng/ml. Embryo transfer will be performed on the fifth day of progesterone.
Locations(1)
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NCT06307184