RecruitingPhase 3NCT06313567

Metronomic Capecitabine in Stage III Gastric Cancer

Metronomic Capecitabine as Adjuvant Therapy in Stage III Gastric Cancer: a Multicentre, Open-label, Parallel-group, Randomised, Controlled, Phase 3 Trial


Sponsor

Fudan University

Enrollment

722 participants

Start Date

Mar 10, 2024

Study Type

INTERVENTIONAL

Conditions

Summary

The purpose of this study is to find out whether treatment with metronomic capecitabine will improve the survival of gastric cancer patients with stage III who had received standard treatment.


Eligibility

Min Age: 18 YearsMax Age: 80 Years

Plain Language Summary

Simplified for easier understanding

This study is testing whether adding low-dose, continuous oral chemotherapy (metronomic capecitabine) after surgery helps prevent recurrence in patients with stage III gastric (stomach) cancer who have already completed standard surgery and treatment. **You may be eligible if...** - You are between 18 and 80 years old - You have been diagnosed with primary stage III stomach cancer confirmed by pathology - You have had successful complete (R0) surgery with removal of surrounding lymph nodes - Your general health is good (ECOG 0 or 1) and you are expected to live more than 6 months - Your blood counts, liver, kidney function, and heart test (ECG) are within normal ranges **You may NOT be eligible if...** - You have previously received chemotherapy, radiation, immunotherapy, or targeted therapy - You have multiple primary cancers - You have serious heart, lung, kidney, or liver disease - You have poorly controlled diabetes or other chronic conditions Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGMetronomic capecitabine group

500 mg/m2 body surface area twice daily for 1 year; metronomic capecitabine group

OTHERObservation

observation


Locations(1)

Fudan University Shanghai Cancer Center

Shanghai, Shanghai Municipality, China

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NCT06313567


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