Screening Study of Combined Sequential Chemotherapy and Radiation Therapy for Early-stage NK/T-cell Lymphoma

This study is testing a combination of sequential chemotherapy followed by radiation therapy for patients with early-stage NK/T-cell lymphoma — a rare and aggressive type of lymphoma that most commonly affects the nasal cavity and upper airway. Researchers want to find the best sequencing and response-adapted approach for this cancer. **You may be eligible if...** - You have been diagnosed with NK/T-cell lymphoma (NKTCL) confirmed by biopsy - Your cancer is located in the upper airway (nasal cavity, sinuses, nasopharynx, oropharynx, or mouth) - Your disease is early stage (IE or IIE) based on PET/CT and bone marrow assessment - You are between 18 and 75 years old - You have not received any prior treatment for lymphoma - Your general health is acceptable (ECOG 0–2) with adequate organ and bone marrow function **You may NOT be eligible if...** - You have received prior chemotherapy, radiation, or immunotherapy for lymphoma - Your cancer has spread beyond the upper airway lymphoma stage criteria - You have poor organ function that would prevent safe chemotherapy Talk to your doctor to see if this trial is right for you.