Effect of CPAP Treatment in Patients With Severe Uncontrolled Asthma: The ASTHMA-SLEEP Trial

This study (ASTHMA-SLEEP trial) is testing whether CPAP therapy (the breathing machine used to treat sleep apnea) can help control severe, uncontrolled asthma in patients who also have moderate-to-severe sleep apnea. Researchers suspect that untreated sleep apnea may make asthma harder to control. **You may be eligible if...** - You are over 18 years old - You have a diagnosis of severe, uncontrolled asthma according to standard guidelines - You have moderate-to-severe sleep apnea (apnea-hypopnea index of 15 or more events per hour on a sleep study) - Your daytime sleepiness score is low (Epworth Sleepiness Scale 10 or below — meaning the sleep apnea is not causing obvious daytime drowsiness) - You have not been hospitalized for asthma in the month before joining the study **You may NOT be eligible if...** - You are already being treated with CPAP - You have central sleep apnea or Cheyne-Stokes breathing (a different type of breathing problem) - You have other sleep disorders (narcolepsy, restless legs syndrome, or chronic insomnia), resistant high blood pressure, or are an active smoker - You are pregnant or have a life expectancy under 1 year Talk to your doctor to see if this trial is right for you.