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RecruitingNot ApplicableNCT06314477

Effect of CPAP Treatment in Patients With Severe Uncontrolled Asthma: The ASTHMA-SLEEP Trial

Effect of CPAP Treatment on Asthma Control in Patients With Severe Uncontrolled Asthma and Obstructive Sleep Apnea: The ASTHMA-SLEEP Study

Sponsor

Hospital Clinic of Barcelona

Enrollment

138 participants

Start Date

Dec 27, 2023

Study Type

INTERVENTIONAL

Conditions

AsthmaObstructive Sleep Apnea

Summary

The aim of the study is to evaluate the impact of CPAP treatment on asthma control in patients with severe uncontrolled asthma and obstructive sleep apnea (OSA)

Eligibility

Min Age: 18 Years

Inclusion Criteria5

  • Age \>18 years
  • Diagnosis of severe uncontrolled asthma according to the criteria of the Spanish Asthma Management Guide (GEMA) or the Global Initiative for Asthma (GINA) and no hospitalizations the month prior to inclusion in the study.
  • Apnea hypopnea rate greater than or equal to 15/hour
  • Punctuation in the Epworth Sleepiness Scale ≤10
  • Obtaining informed consent.

Exclusion Criteria9

  • Previous treatment with CPAP
  • Patient with central sleep apnea or Cheyne-Stokes respiration
  • Other sleep disorders: narcolepsy, restless leg syndrome, chronic insomnia,
  • Resistant hypertension
  • Active Smoking
  • Unstable comorbidities or medications may interfere with asthma control
  • Pregnancy
  • Any process that reduces life expectancy to \<1 year,
  • Any medical or social factor that may limit CPAP compliance

Interventions

DEVICECPAP treatment

Subjects allocated to this arm will receive continuous positive airway pressure (CPAP)

OTHERHygienic and dietary advice

Subjects allocated to this arm will receive hygienic and dietary counselling

Locations(1)

Hospital Clinic Barcelona

Barcelona, Spain, Spain

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NCT06314477

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