RecruitingPhase 1NCT06315257

A Clinical Trial to Assess PVX7 Immunotherapy Regimens in Advanced Cervical Cancer Patients

A Randomized, Open-label Clinical Trial to Assess the Safety, Feasibility and Immunogenicity of Adjuvant PVX7 Immunotherapy Regimens in Advanced Cervical Cancer Patients


Sponsor

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

Enrollment

32 participants

Start Date

Sep 22, 2025

Study Type

INTERVENTIONAL

Conditions

Summary

A Feasibility Trial of PVX7 vaccine in advanced cervical cancer patients who have completed primary definitive therapy.


Eligibility

Sex: FEMALEMin Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is testing a cancer vaccine called PVX7 in women who have completed primary treatment for advanced cervical cancer (stages IB1 through IVA) and are currently in remission. The goal is to see if this immunotherapy approach can help the immune system recognize and prevent cancer from coming back. **You may be eligible if...** - You are a woman aged 18 or older - You have been diagnosed with advanced cervical cancer (stage IB1–IVA) and completed primary treatment (surgery, radiation, and/or platinum-based chemotherapy) within the past 12 months - You currently show no evidence of remaining or returning cancer on imaging and clinical assessment - You may also be receiving or recommended to receive anti-PD-1/PD-L1 immunotherapy, which can continue during this study - You are HIV-negative, Hepatitis B surface antigen-negative, and Hepatitis C-negative **You may NOT be eligible if...** - You have evidence of remaining or recurrent cancer - You are HIV-positive or have active hepatitis B or C infection - You have received the study drug previously or do not meet safety criteria for immunotherapy Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGPVX7

PVX7 Immunotherapy


Locations(2)

The University of Alabama at Birmingham

Birmingham, Alabama, United States

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

Baltimore, Maryland, United States

View Full Details on ClinicalTrials.gov

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NCT06315257


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