Is Local Injection of Mesenchymal Stem Cells After Endoscopic Dilation Safe and Does it Improve the Outcome of Intestinal Stricture in Patients With Crohn's Disease?

This study investigates whether injecting stem cells (mesenchymal stem cells) directly into a narrowed section of the intestine — right after stretching it open with a procedure called endoscopic dilation — can help prevent the narrowing from coming back in patients with Crohn's disease. **You may be eligible if...** - You are 18 years or older and have had Crohn's disease for more than 6 months - Your medication for Crohn's disease has been stable for the past 4 months - You have an intestinal narrowing (stricture) that can be seen on imaging and causes symptoms like pain after eating - The narrowing is accessible via colonoscopy and short enough to treat **You may NOT be eligible if...** - You have a stricture longer than 5 cm, or multiple strictures, or one with a suspected cancer - You have an active abscess or fistula near the stricture - You have certain other serious medical conditions - You are pregnant or breastfeeding Talk to your doctor to see if this trial is right for you.