Biomarker-driven Phenotypic Dissection of Amyotrophic Lateral Sclerosis
Dissezione Fenotipica Guidata da Biomarcatori Della Sclerosi Laterale Amiotrofica/Biomarker-driven Phenotypic Dissection of Amyotrophic Lateral Sclerosis
Istituto Auxologico Italiano
200 participants
Apr 11, 2023
OBSERVATIONAL
Conditions
Summary
The goal of this observational study is to understand the clinical variability in a population of ALS patients using multidimensional biomarkers. The main questions it aims to answer are: * Which set of biomarkers explain genotypic-phenotypic correlations in ALS? * Which set of biomarkers can be used to subdivide the ALS population in homogeneous subgroups? Participants will undergo: * neurological evaluation * neurophysiological evaluation * neuropsychological evaluation * whole exome sequencing * biomarker measurement in CSF and plasma
Eligibility
Inclusion Criteria2
- diagnosis of ALS or other motor neuron disease
- residence near the study centers
Exclusion Criteria2
- refusal to participate to the study
- unable/unwilling to perform follow-up visits
Interested in this trial?
Get notified about updates and connect with the research team.
Locations(3)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT06318598