RecruitingPhase 1NCT06321484

Intraperitoneal Cytokine-Induced Memory Like (CIML) Natural Killer (NK) Cells in Recurrent Ovarian Cancer

A Phase 1b Study of Cytokine-Induced Memory Like (CIML) Natural Killer (NK) Cell Therapy in Recurrent Ovarian Cancer


Sponsor

Dana-Farber Cancer Institute

Enrollment

18 participants

Start Date

Oct 9, 2024

Study Type

INTERVENTIONAL

Summary

The goal of this research study is to evaluate the safety and effectiveness of the use of cytokine-induced memory-like (CIML) natural killer (NK) cell therapy in recurrent, high grade ovarian cancer (HGOC). Names of the study therapies involved in this study are: CIML NK (cellular therapy) Interleukin-2 (IL-2)


Eligibility

Min Age: 18 YearsMax Age: 85 Years

Plain Language Summary

Simplified for easier understanding

This study is testing a new type of immune cell therapy — called CIML natural killer (NK) cell therapy — delivered directly into the abdomen to treat ovarian cancer that has come back after prior treatment. NK cells are immune cells that can recognize and destroy cancer cells. **You may be eligible if:** - You are 18 years or older - You have been diagnosed with recurrent epithelial ovarian cancer (specifically high-grade serous, high-grade endometrioid, or clear cell type) - Your cancer shows measurable disease on scans - You have received at least 1 prior treatment and your cancer is resistant to or you cannot tolerate platinum-based chemotherapy - If you carry a BRCA1 or BRCA2 gene mutation, you must have previously tried a PARP inhibitor drug **You may NOT be eligible if:** - You have not received any prior treatment for ovarian cancer - You experienced severe (grade 3+) side effects from prior immunotherapy - You do not have measurable disease on scans Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

BIOLOGICALCytokine-Induced Memory-like Natural Killer Cells

Cytokine Induced Memory-like Natural Killer (CIML NK) Cells Autologous, cytokine induced memory-like natural killer cells, via intraperitoneal (IP) infusion per protocol.

DRUGInterleukin 2

Low dose subcutaneous IL-2 will be administered every other day for 5 doses after CIML NK cell infusion


Locations(2)

Brigham and Women's Hospital

Boston, Massachusetts, United States

Dana-Farber Cancer Institute

Boston, Massachusetts, United States

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NCT06321484