Exploring Approaches With Lower Targets of Blood Pressure and Lipid for Improving Renal Outcome in Advanced Chronic Kidney Disease

This study is exploring whether more aggressive lowering of blood pressure and cholesterol can slow the progression of advanced chronic kidney disease (CKD). Researchers will compare standard treatment targets against lower targets to see which approach better preserves kidney function. **You may be eligible if:** - You are at least 19 years old - You have chronic kidney disease diagnosed at least 3 months ago, with a moderately reduced kidney filtration rate (eGFR 15–45) - Your systolic blood pressure (the top number) is above 130 mmHg - Your LDL cholesterol is 100 mg/dL or higher **You may NOT be eligible if:** - You have resistant high blood pressure not controlled despite 4 or more medications - You have a known secondary cause of high blood pressure - You have had a kidney denervation procedure - You have kidney inflammation requiring immune-suppressing drugs - You have polycystic kidney disease (autosomal dominant type) Talk to your doctor to see if this trial is right for you.