RecruitingNot ApplicableNCT06322329

RealMove (Lung): Assessing Tumour Motion With Dynamic MRI


Sponsor

Region Stockholm

Enrollment

150 participants

Start Date

Mar 15, 2024

Study Type

INTERVENTIONAL

Conditions

Summary

The study aims to develop an improved method to tailor the geometric safety margin when treating with stereotactic body radiotherapy (SBRT), to avoid tumour cells being missed during irradiation and to limit the exposure of normal tissues as much as possible. Dynamic magnetic resonance imaging (MRI) is assumed to represent the tumour motion during the respiratory cycle more realistically, compared to 4-dimensional computed tomography (4D CT), thanks to its high temporal resolution and the possibility to image the motion over a longer period of time. Patients receiving SBRT for a pulmonary target located below the level of the carina are included in the study, and the hypothesis will be tested through a comparison of the tumour amplitude measured with each modality. Furthermore, the predictive value of the image series acquired at treatment planning, for the motion patterns observed at each treatment fraction, will be evaluated through repeated 4D CBCT acquisitions.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is looking at using a type of MRI scan that captures movement (called dynamic MRI) to more precisely measure how lung tumors shift during breathing. This information could help radiation therapists plan more accurate treatments that better protect healthy tissue around the tumor. **You may be eligible if:** - You have been approved for a type of focused radiation treatment (SBRT) for one or more lung tumors (either lung cancer or cancer that has spread to the lung) located in the lower portion of the lung - You are 18 years or older - You are physically able to lie still in a fixed position for at least 30 minutes - You have adequate Swedish language skills and cognitive ability to complete study materials **You may NOT be eligible if:** - You are pregnant, breastfeeding, or planning pregnancy during your treatment - You have a contraindication to MRI (such as certain metal implants) - You are otherwise unable to participate in the study Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

OTHERDynamic MRI

Subjects receive a study-specific dynamic MRI scan. If the hypothesis of the study is confirmed, this examination can be used to inform future patients' treatment planning, replacing the use of 4D CT.


Locations(1)

Karolinska University Hospital

Stockholm, Sweden

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NCT06322329


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