RecruitingNot ApplicableNCT06322420

Behavioral Activation for Depression and Habitual Rumination

Mood-reactive Habitual Rumination and Changes During Behavioral Activation Treatment for Major Depression

Sponsor

Ragnar Pétur Ólafsson

Enrollment

120 participants

Start Date

Feb 9, 2024

Study Type

INTERVENTIONAL

Conditions

Major Depressive Disorder

Summary

Depressive rumination, a negative thinking style characterized by repetitive and passive thoughts about the causes, meanings, and consequences of one's feelings and distress, is often described as being a habitual response tendency that forms a vulnerability to depression. Behavioural Activation (BA) is an effective treatment for depression but little is known of mechanisms of changes during a successful treatment completion and for whom the treatment benefits the most. The main purpose of the study is to investigate whether habit-like mood-reactive rumination will change during Behavioral Activation treatment for current depression and mediates symptom changes in the treatment. Important moderators of change will also be investigated (i.e. history of early life stress and cognitive flexibility). We aim to provide individual BA treatment for up to 120 currently depressed participants (from 90 to 120 participants) in 12 treatment sessions over 11 weeks. Measures are obtained at pre-treatment, during treatment, at post-treatment and at 6 month follow up.

Eligibility

Min Age: 18 YearsMax Age: 65 Years

Plain Language Summary

Simplified for easier understanding

This study is testing a type of therapy called Behavioral Activation (BA) for people with depression who also tend to ruminate — meaning they get stuck in repetitive, negative thinking loops. Behavioral Activation works by encouraging people to engage in meaningful activities to improve mood. **You may be eligible if:** - You are between 18 and 65 years old - You have been diagnosed with a current major depressive episode as your primary condition - Your depression severity score on the BDI-II is 14 or higher - You understand Icelandic well enough to complete study measures - You are able to complete an initial assessment including two visits and a 6-day daily diary exercise **You may NOT be eligible if:** - You have a history of manic or hypomanic episodes (bipolar disorder) - You have a history of psychosis - You have another primary psychiatric diagnosis that is not depression - You are unable to complete the study requirements Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

BEHAVIORALBehavioural Activation (BA)

Behavioural activation treatment delivered in this single arm study. Individual treatment given to all participants in 12 sessions over 11 weeks. All treatment components have been introduced by session 8 that defines minimum amount of treatment in the trial (i.e. 8 session completed). Behavioral Activation is a psychological treatment for depression focused on gradually re-engaging people with sources of reinforcement and reward in their environment by re-establish healthy patterns of activity, and replace avoidance behaviours with more adaptive behaviours.

Locations(1)

University of Iceland

Reykjavik, Iceland, Iceland

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NCT06322420

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