RecruitingNCT06323278

Effectiveness of Cognitive Stimulation Treatment in Patients With Parkinson's Disease

Evaluation of the Cognitive Stimulation Treatment in Patients With Parkinson's Disease

Sponsor

Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico

Enrollment

68 participants

Start Date

Dec 21, 2021

Study Type

OBSERVATIONAL

Conditions

Parkinson Disease

Summary

The goal of this observational study is to evaluate the relationship between GBA mutation and cognitive stimulation treatment response in patients with Parkinson's disease. The main questions it aim to answer are: • assess whether the GBA mutation is associated with greater or lesser response to cognitive training treatment compared to a control group of PD patients without genetic mutations. • investigate the effect of cognitive stimulation program on behavioural aspects as secondary consequence induced by the possible improvement of cognitive abilities following treatment. Participants will be undergo to: - a neuropsychological evaluation describing their cognitive profile; - a genetic investigation and finally included in a cognitive stimulation programs according to regular clinical practice. Researchers will compare PD patients with GBA mutation and patients without genetic mutation to evaluate the effectiveness of cognitive stimulation treatment.

Eligibility

Min Age: 18 YearsMax Age: 80 Years

Plain Language Summary

Simplified for easier understanding

This study is evaluating whether a cognitive stimulation program — structured activities designed to keep the mind active and engaged — can help improve thinking and memory in people with Parkinson's disease who have mild cognitive impairment (not full dementia). **You may be eligible if:** - You have been diagnosed with Parkinson's disease - You have had genetic screening for Parkinson's disease - Your score on the Montreal Cognitive Assessment (MoCA) falls in the mild impairment range (between 15.50 and 22.23) - You are already enrolled in a cognitive stimulation program as part of your regular care - You have signed informed consent **You may NOT be eligible if:** - It turned out during evaluation that you have a different condition than Parkinson's disease - You have Parkinson's-related dementia (severe cognitive decline) - You are being treated with deep brain stimulation (DBS) - You have refused to participate Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

BEHAVIORALCognitive training

The training, provided by normal clinical practice, will consist of two cycles of cognitive stimulation (8 sessions each) structured and aimed at maintaining and learning compensatory strategies that take advantage of the integrated cognitive skills.