RecruitingNot ApplicableNCT06324825

Fuzheng Nizeng Formula for Chronic Atrophic Gastritis With Low-grade Intraepithelial Neoplasia, a Multicenter Randomized Controlled Trial

Fuzhegn Nizeng Formula for Chronic Atrophic Gastritis With Low-grade Intraepithelial Neoplasia, a Multicenter Randomized Controlled Trial


Sponsor

Peking University First Hospital

Enrollment

144 participants

Start Date

Oct 24, 2022

Study Type

INTERVENTIONAL

Conditions

Summary

Fuzheng Nizeng Formula (FZNZ) is derived from the classic formula Liujunzi Decoction. Former pilot study found that FZNZ promoted the recovery of gastric atrophy and relieve the relative symptoms. This study is to evaluate its efficacy for chronic atrophic gastritis with low-grade intraepithelial neoplasia, compared with positive control Molduodan granule.


Eligibility

Min Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study is testing a traditional Chinese herbal medicine formula called Fuzheng Nizeng for treating chronic atrophic gastritis with low-grade dysplasia (a condition where the stomach lining becomes thin and some cells show early abnormal changes that could potentially progress toward cancer over time). **You may be eligible if:** - You have been diagnosed with chronic atrophic gastritis with low-grade intraepithelial neoplasia (confirmed by endoscopy and biopsy) - You have tested negative for Helicobacter pylori (a stomach bacteria) - Your condition matches a specific traditional Chinese medicine (TCM) pattern called "spleen-stomach deficiency with blood stasis and phlegm" **You may NOT be eligible if:** - You have had prior stomach surgery - You have been diagnosed with a malignant tumor (cancer) - You have a history of mental illness - You have a known allergy to any components of the study drugs - You are planning a pregnancy, currently pregnant, or breastfeeding Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGFuzhegn Nizeng Decoction

Subjects taking prepared Fuzhegn Nizeng granules twice daily for 6 month.

DRUGMoluodan granules

Subjects taking prepared Moluodan granules 9g twice daily for 6 month.


Locations(1)

Peking University First Hospital

Beijing, Beijing Municipality, China

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NCT06324825