RecruitingNCT06325280

Exercise MRI to Evaluate Cardiorespiratory Fitness in Children With Heart Disease

Utilizing Exercise Cardiovascular and Skeletal Magnetic Resonance Imaging to Evaluate Factors Associated With Cardiorespiratory Fitness in Children With Acquired and Congenital Heart Disease

Sponsor

University of Alberta

Enrollment

20 participants

Start Date

Jan 20, 2025

Study Type

OBSERVATIONAL

Conditions

Pediatric ALL Congenital Heart Disease Heart Transplantation

Summary

There are many barriers to heart-healthy lifestyles in pediatric patients with acquired and congenital heart disease. Investigators want to further understand how participants heart and skeletal muscles work together during exercise and evaluate the impact on cardiac function. To do this, the investigators will use magnetic resonance imaging (MRI) to scan the heart and skeletal muscles during exercises to assess blood flow, oxygenation and function.

Eligibility

Min Age: 10 YearsMax Age: 18 Years

Plain Language Summary

Simplified for easier understanding

This study uses special MRI scans taken while children exercise to measure how fit their hearts and lungs are. It focuses on children with complex heart conditions or those who have received a heart transplant. The goal is to find a better, non-invasive way to assess cardiorespiratory fitness in kids who can't do standard exercise stress tests easily. **You may be eligible if...** - You are between 10 and 18 years old - You are followed at Stollery Children's Hospital - You received a heart transplant at least 6 months ago, OR you have a moderate-to-complex congenital (birth-related) heart condition **You may NOT be eligible if...** - You do not speak English - Your cardiologist has restricted your physical activity - You had a transplant rejection episode within the last 3 months - You have previously had an exercise stress test showing dangerous heart rhythm problems, blood pressure issues, chest pain, or fainting - Your resting blood oxygen level is below 85% or you require supplemental oxygen Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DIAGNOSTIC_TESTExercise cardiac MRI Assessment

Participants will undergo a standard cardiac MRI to assess resting ventricular structure and function then complete an exercise cardiac MRI assessment using an MRI-compatible stepping ergometer.

DIAGNOSTIC_TESTCardiopulmonary Exercise Test

Cardiopulmonary exercise testing will be performed using a cycle ergometer. Consistent with standard guidelines, workload will progressively increase (10W ramp protocol) such that peak oxygen consumption (VO2peak) is achieved within 8-12 minutes. VO2peak, VO2 at anaerobic threshold, peak power output (PPO), ventilation/carbon dioxide production (VE/VCO2) slope, peak heart rate (HR), and HR recovery at 1- and 3-minutes will be recorded. VO2peak will be converted to age-, weight, and sex-specific norms and a %predicted value.