Pancreatic Cancer Screening in a Population at High Risk

This study is offering structured surveillance (regular monitoring and early detection screening) for pancreatic cancer in people who are at higher-than-average risk due to genetic mutations, hereditary syndromes, family history, or chronic pancreatic conditions. Early detection dramatically improves outcomes for pancreatic cancer, which is often caught too late. **You may be eligible if:** - You are 18 or older and willing to participate - You have chronic pancreatic disease due to cystic fibrosis or chronic pancreatitis (and are age 50+) - You carry a gene mutation linked to hereditary cancer syndromes (such as Peutz-Jeghers, CDKN2A, PRSS1, Lynch syndrome, BRCA1/2, PALB2, ATM, APC, TP53 and others) combined with a qualifying age or family history of pancreatic cancer - You have a strong family history of pancreatic cancer without a known hereditary syndrome (and are age 50+, or 10 years younger than the youngest affected relative) **You may NOT be eligible if:** - You are medically unable to undergo curative surgery if cancer were found - You do not meet age or risk-factor requirements for any of the study arms Talk to your doctor to see if this trial is right for you.