RecruitingNot ApplicableNCT06330545

Radiation Therapy for Dupuytren's Contracture Following Non-Surgical Release

A Prospective Clinical Trial of Radiation Therapy for Dupuytren's Contracture Following Surgical and Non-Surgical Release

Sponsor

Dartmouth-Hitchcock Medical Center

Enrollment

95 participants

Start Date

Sep 16, 2024

Study Type

INTERVENTIONAL

Conditions

Dupuytren Contracture

Summary

The goal of this study is to learn about preventing recurrence of Dupuytren's Contracture. The main question it aims to answer are: • Does targeted radiation therapy decrease recurrence of Dupuytren's contracture after treatment with Collagenase Clostridium Histolyticum? Participants will undergo: * Release of Dupuytren's Contracture after Collagenase Clostridium Histolyticum injection * Daily radiation therapy treatment for 5 days followed by 6-8 week rest period and then another course of 5 days of radiation therapy

Eligibility

Min Age: 45 Years

Inclusion Criteria5

Age 45 or greater with DC
Extension deficit >10 degrees
Unable to simultaneously place the affected finger and palm flat on a table.
Women included in the study will be post-menopausal or using contraception, and a pregnancy test will be performed as standard of care.
For patients who are having multiple CCH injections, only the first 2 joints on given hand will be included

Exclusion Criteria7

Unsuccessful non-surgical release (> N/1 disease)
They develop an open wound during CCH
Breast feeding or pregnancy
A chronic muscular, neurologic, or neuromuscular disorder affecting the hands.
Less than the age of 45
They have previously undergone radiation on the hand in which they plan to get CCH injections
They are pregnant women, impaired adults or prisoners

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Interventions

RADIATIONRadiation therapy

Patients with Dupuytren's Contacture will undergo Collagenase Clostridium Histolyticum injection and release followed by two 5-day courses of radiation therapy separated by 6-8 weeks. They will then be followed for 3 years for recurrence.