Cardiometabolic Function in Offspring, Mother and Placenta After Assisted Reproductive Technology
Rigshospitalet, Denmark
600 participants
May 17, 2024
OBSERVATIONAL
Conditions
Summary
The overall objective is to establish the first-of-its-kind longitudinal cohort of pregnant women, biological fathers/partners and offspring from pregnancies achieved by frozen embryo transfer (FET), fresh-embryo transfer (fresh ET) and naturally conceived (NC) to investigate maternal cardiometabolic profiles, fetal growth patterns and placental function during pregnancy as well as metabolic and endocrine health in the offspring. Additionally, the aim is to explore genetic and epigenetic patterns in placenta, fetus and parents. As secondary objectives, the investigator group will examine telomere length and minipuberty hormones in children born after FET, fresh-ET and NC.
Eligibility
Inclusion Criteria1
- Pregnant women who have either had fertility treatment at Rigshospitalet or Herlev Hospital (FET and fresh ET groups) or are scheduled for prenatal ultrasounds at Rigshospitalet or Herlev Hospital (NC group) will be screened for eligibility. Inclusion must happen before their routine ultrasound scan in 1. trimester.
Exclusion Criteria5
- Maternal pregestational diabetes type 1 or 2
- Non-singleton pregnancies
- Maternal pregestational BMI \> 35 kg/m2
- Severe maternal co-morbidity
- Oocyte donation
Interested in this trial?
Get notified about updates and connect with the research team.
Locations(3)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT06334003