A Prospective Study of Vasopressor on Cerebral Oxygenation During General Anesthesia
Effects of Vasopressor on Cerebral Oxygenation During General Anesthesia in Abdominal Surgery
Dalian Municipal Central Hospital
180 participants
Mar 5, 2024
INTERVENTIONAL
Conditions
Summary
The purpose of this study is to investigate whether norepinephrine(N), phenylephrine(P) or ephedrine(E) have different effect on cerebral oxygenation in abdominal surgery with propofol or sevoflurane.
Eligibility
Inclusion Criteria3
- ASA I-III, age 18-80 years
- Elective abdominal surgery
- Signed informed consent
Exclusion Criteria5
- ASA≥IV
- Preoperative unstable blood hemodynamics
- Allergy to ephedrine, phenylephrine or norepinephrine
- Decrease in MAP \<20%
- Severe cardiovascular disorder
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Interventions
after induction of anesthesia, use total intravenous anesthesia maintained with propofol
after induction of anesthesia, use total intravenous anesthesia maintained with propofol
after induction of anesthesia, use total intravenous anesthesia maintained with propofol
after induction of anesthesia, use inhalation anesthesia maintained with sevoflurane
after induction of anesthesia, use inhalation anesthesia maintained with sevoflurane
after induction of anesthesia, use inhalation anesthesia maintained with sevoflurane
Locations(1)
View Full Details on ClinicalTrials.gov
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NCT06334549