Understanding the Mechanisms of Autism : an MRI and Social Cognition Study
Assistance Publique - Hôpitaux de Paris
160 participants
Apr 17, 2024
INTERVENTIONAL
Conditions
Summary
The main goal of this study is to investigate anatomo-functional brain abnormalities associated with autism spectrum disorders using a multimodal brain imaging approach, as well as its links to social cognition difficulties measured using eye-tracking
Eligibility
Inclusion Criteria15
- For subjects diagnosed with ASD or suspected of ASD :
- months ≤ age < 25 years ;
- an MRI required as part of the clinical procedures
- written consent obtained from parents or legal guardians.
- Affiliated to social security
- For Healthy control subjects over 3 years of age:
- between 3 and 28 years of age
- no known neurological or psychiatric pathology
- written consent obtained from parents or legal guardian.
- Affiliated to social security
- For Healthy control subjects under 5 years of age:
- age between 3 months and 5 years
- who have had an MRI scan in the pediatric radiology department at Necker Hospital, which was found to be normal.
- with no known neurological or psychiatric pathology
- no opposition from legal representative
Exclusion Criteria2
- Contraindication to MRI (pacemaker, intracorporeal metallic body, claustrophobia).
- Impossibility for healthy volunteers to remain still during MRI
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Interventions
Anatomical and functional images will be acquired and review by an experienced neuro-radiologist
Eye movements and follow a person's gaze will be recorded during visualization of stimuli presented in the screen by analyzing images of the eye captured by an infrared camera
CGI, E-CAR and ABC will be used for behavior and clinical evaluation
For the diagnosis of autism, patients benefit from a a genetic assessment. This is carried out as part of their care
Locations(1)
View Full Details on ClinicalTrials.gov
For the most up-to-date information, visit the official listing.
NCT06334588