RecruitingPhase 2NCT06336395

Ma-Spore ALL 2020 Study

Ma-Spore ALL-Seq 2020: RNA-Seq and IgH/TCR-Seq to Improve Risk Assignment in Childhood, Adolescent and Young Adult Acute Lymphoblastic Leukaemia


Sponsor

National University Hospital, Singapore

Enrollment

500 participants

Start Date

Mar 4, 2020

Study Type

INTERVENTIONAL

Conditions

Summary

The primary objective of this trial is to improve the overall survival rate of children and young adult with B-lineage acute lymphoblastic leukemia (B-ALL) in Singapore and Malaysia in the context of a multicenter cooperative trial using a risk-stratified therapy.


Eligibility

Max Age: 40 Years

Plain Language Summary

Simplified for easier understanding

This study (Ma-Spore ALL 2020) is evaluating a treatment protocol for B-cell acute lymphoblastic leukemia (ALL) — a cancer of the white blood cells — in children, adolescents, and young adults across Malaysia and Singapore. The goal is to improve treatment outcomes using a risk-adapted approach. **You may be eligible if...** - You are under 41 years old - You have been newly diagnosed with B-cell acute lymphoblastic leukemia (B-ALL), confirmed by bone marrow testing and cell typing - You (or your legal guardian) have provided written informed consent **You may NOT be eligible if...** - You have T-cell ALL (a different subtype) - You have Down syndrome with ALL - You have had a prior cancer or this is a second leukemia - You have mixed-lineage or undifferentiated leukemia - You have already received chemotherapy, radiation, or immunotherapy for this condition (short-term steroids under 7 days may be acceptable) Talk to your doctor to see if this trial is right for you.

This summary was AI-generated to explain the trial in plain language. It is not medical advice. Always discuss eligibility with your doctor before enrolling in a clinical trial.

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Interventions

DRUGPrednisolone

Oral

DRUGDexamethasone

Oral

DRUGVincristine

Intravenous

DRUGMethotrexate

Oral/ intrathecal/intravenous/subcutaneous

DRUGL-Asparaginase

Intramuscular

DRUGPegylated asparaginase

Intravenous

DRUGErwinase

Optional for those allergic to E.coli/PEG L-asparaginase (intravenous)

DRUGDasatinib

Indicated only for ALL with BCR::ABL1 /BCR::ABL1-like/ tyrosine kinase fusion positive (oral)

DRUGImatinib

Indicated only for ALL with BCR::ABL1 /BCR::ABL1-like/ tyrosine kinase fusion positive (oral)

DRUGCyclophosphamide

Intravenous

DRUGCytarabine

Subcutaneous/ Intravenous

DRUGMercaptopurine

Oral

DRUGThioguanine

Oral

DRUGRituximab

Intravenous

DRUGDoxorubicin

Intravenous

DRUGFludarabine

Intravenous


Locations(3)

Subang Jaya Medical Centre

Kuala Lumpur, Malaysia

University Malaya Medical Centre

Kuala Lumpur, Malaysia

KK Women's and Children's Hospital

Singapore, Singapore

View Full Details on ClinicalTrials.gov

For the most up-to-date information, visit the official listing.

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NCT06336395