To Evaluate the Dose-response Effects of a Defined Volume of Physical Exercise on the Change of Peripheral Biomarkers, Clinical Response and Brain Connectivity in Parkinson's Disease: a Prospective, Observational, Cohort Pilot Study

This observational pilot study examines how different doses of physical exercise affect brain function, blood markers, and movement in people with Parkinson's disease. It aims to understand the "dose-response" relationship between exercise and the brain, potentially informing personalized exercise prescriptions. **You may be eligible if...** - You have been diagnosed with Parkinson's disease (per UK Parkinson's Disease Society Brain Bank criteria) - You are between 30 and 80 years old - Your Parkinson's is in stages II–III (moderate), while your medication is working - You have adequate cognitive function (MMSE ≥ 24 and MoCA ≥ 17/30) - You are on a stable Parkinson's medication regimen - You are physically able to walk for a 6-minute walk test **You may NOT be eligible if...** - You have another neurological condition unrelated to Parkinson's - You have musculoskeletal problems that impair walking or exercise - You have significant cardiovascular disease, diabetes, uncontrolled high blood pressure, or thyroid/kidney/liver abnormalities - You have orthostatic hypotension (blood pressure drops significantly when you stand up) Talk to your doctor to see if this trial is right for you.